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First-Line Osimertinib/Bevacizumab for Metastatic EGFR-Mutant Lung Cancer ResearchTreatments

First-Line Osimertinib/Bevacizumab for Metastatic EGFR-Mutant Lung Cancer

*July 2020* In the trial, 49 patients enrolled between August 2016 and May 2018 at Memorial Sloan Kettering Cancer Center received osimertinib at 80 mg daily and bevacizumab at 15 mg/kg once every 3 weeks, the maximum-tolerated dose identified in the phase I portion of the trial. The primary outcome…
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September 18, 2020
targeted oncology
Almonertinib Induces Response in EGFR T790M-Positive NSCLC With CNS Metastases ResearchTreatments

Almonertinib Induces Response in EGFR T790M-Positive NSCLC With CNS Metastases

*May 2020* The study results indicated clinical efficacy against central nervous system metastases in a cohort of patients. Almonertinib also displayed an overall favorable safety profile. Clinical benefit was observed with almonertinib (HS-10296) as treatment of patients with EGFR T790M-mutant non–small cell lung cancer (NSCLC) who progressed on previous EGFR tyrosine kinase inhibitors…
Onc Live
Building On Immunotherapy, Preventing Acquired Resistance Are Next Steps in Lung Cancer Research ResearchTreatments

Building On Immunotherapy, Preventing Acquired Resistance Are Next Steps in Lung Cancer Research

*March 2020* Checkpoint inhibitors and next-generation TKIs have demonstrated improved survival outcomes in patients with non–small cell lung cancer (NSCLC); however, ongoing research efforts are looking to build upon the benefits with combination strategies and prevent acquired resistance to treatment, explained David P. Carbone, MD, PhD. “It's an incredibly exciting…