Research

*June 2025* Raffaele Califano, MD, of the Christie NHS Foundation Trust and the University of Manchester, discusses outcomes by osimertinib resistance mechanisms in MARIPOSA-2, a study that evaluated the efficacy of the bispecific antibody amivantamab-vmjw plus chemotherapy vs chemotherapy in patients with EGFR-mutant advanced NSCLC after disease progression on osimertinib. Watch video…

*June 2025* The antibody-drug conjugate patritumab deruxtecan (HER3-DXd) did not improve overall survival (OS) compared with platinum-based chemotherapy in patients with EGFR mutation–positive locally advanced or metastatic non–small cell lung cancer (NSCLC), according to results from the phase 3 HERTHENA-Lung02 trial (NCT05338970) presented at the 2025 American Society of Clinical Oncology (ASCO) Annual…

*April 2025* Note: The following is an abstract from AACR 2025 presenting data on this new clinical trial, SOLARA (NCT06706076) Outcomes on tyrosine kinase inhibitor (TKI) treatment in EGFR-mutant NSCLC fall short of the durable benefit observed with next-generation targeted therapies in ALK and ROS1-driven NSCLC. We reviewed the chemical structures of 30+ existing…

*April 2025* Note: This drug is in the pipeline and is planning to open Phase 1 clinical trials in mid-2025. ALX Oncology (ALXO) has received FDA clearance for its Investigational New Drug (IND) application for ALX2004, a potential first-in-class antibody-drug conjugate (ADC) for treating EGFR-expressing solid tumors. The company plans to initiate Phase…

*April 2025* The ongoing COCOON study of a prophylactic dermatologic regimen in reducing the incidence of skin- and nail-adverse reactions in patients treated with amivantamab plus lazertinib demonstrated “early success” in meeting its phase II primary endpoint, according to a March 27 presentation during the European Lung Cancer Congress (ELCC).…

*April 2025* The investigational oral tyrosine kinase inhibitor (TKI) zongertinib showed promise in patients with previously treated HER2-mutant non-small cell lung cancer (NSCLC) in a multicohort phase Ia/Ib study. In the first cohort of 75 patients with tumors harboring a mutation in the tyrosine kinase domain, the confirmed objective response rate…

*June 2025* Targeted Oncology: What were the outcomes of the MARIPOSA trial (NCT04487080) in patients with EGFR-mutated non–small cell lung cancer (NSCLC)? Xiuning Le, MD, PhD: MARIPOSA is a global phase 3 study that enrolled a total of 1000 patients with EGFR  in the first line. The primary comparison is amivantamab plus…