laurabbook@gmail.com

*August 2023* A supplemental biologics license application (sBLA) seeking the expanded approval of amivantamab-vmjw (Rybrevant) in combination with carboplatin plus pemetrexed for use in the frontline treatment of patients with locally advanced or metastatic non–small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations has been submitted to the FDA.1  …

*July 2023* In this podcast, Dr Tracy Stockley, pathologist and geneticist, University Health Network, and Prof. David Hong, medical oncologist, MD Anderson, come together to provide an introduction to molecular testing. Listen as they discuss: Why identifying genetic alterations is so important How targeted therapies impact outcomes When to use molecular profiling…

*July 2023* Antibody-drug conjugates (ADC) represent one of the most exciting areas of ongoing development for the treatment of patients with non–small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), according to Karen Reckamp, MD, MS, during a presentation at the 24th Annual International Lung Cancer Congress®.1 “This is the…

*June 2023* Lung cancer is a major global health problem, with an estimated 2 million new cases every year and 1.8 million deaths.1 NSCLC is the commonest form and accounts for 85% of all lung cancers.2 Advanced (stage III) and metastatic (stage IV) NSCLC confer the worst prognosis, with 5-year…

*June 2023* In June 2023, Lung Cancer Living Room™ gathered experts such as Dr. Karen Reckamp, Judy Johnson, MBA, and Andrew Ciupek, PhD to discuss and demystify the subject of clinical trials for lung cancer. They started by explaining what clinical trials are, emphasizing that they're not limited to drug…

*September 2023* RARITAN, N.J., Sept. 6, 2023 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson & Johnson today announced positive topline results from the three-arm Phase 3 MARIPOSA-2 study evaluating RYBREVANT® (amivantamab-vmjw), a bispecific antibody targeting epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition (MET), given with and without lazertinib, an oral, third-generation…

*September 2023* This month we have the honor of featuring Paul Stockhammer, MD, PhD. As a third-year resident at Yale School of Medicine last year, Dr Stockhammer received the Distinguished Young Investigator Research Award at the 2022 EGFR Research Summit for his work entitles “Co-occurring Alterations in Multiple Tumor Suppressor…

*July 2023* In the article that accompanies this editorial, Piotrowska et al3 attempt to fill that void with results from a phase I/II study of zipalertinib, an irreversible, oral EGFR TKI in patients with recurrent or metastatic NSCLC harboring EGFR ex20ins mutations. In preclinical models, zipalertinib demonstrated selective inhibition of EGFR ex20ins, with minimal activity…