Research

*March 2024* The publishing of data from the FLAURA21 and MARIPOSA2 trials in the fall of 2023 spurred much discussion and debate about the use of first-line chemotherapy in non-small cell lung cancer (NSCLC) patients with EGFR mutations. To clarify the role of first-line chemotherapy in this population, Suresh S. Ramalingam, MD,…

*March 2024* Stephen V. Liu, MD, Director of Thoracic Oncology and Head of Developmental Therapeutics, Georgetown University, gave an overview of the topics discussed during February’s IASLC Targeted Therapies Meeting. Isabel Preeshagul, DO, MBS, moderated the discussion. Watch it here.

*February 2024* Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment. Researchers at Weill Cornell Medicine have developed a mouse model that illuminates this problematic process, known as…

*February 2024* Abstract Patients with epidermal growth factor receptor (EGFR)–mutated advanced non–small-cell lung cancer represent a distinct subgroup of individuals who can experience initially tolerable and durable effects with first-line EGFR-directed tyrosine kinase inhibitors. Unfortunately, acquired treatment resistance and cancer progression within the CNS are inevitable during the disease course and present…

*April 2024* Highlights Additional frontline options for treating EGFR-mutated NSCLC are required. Lazertinib showed promising efficacy and safety in LASER201 and LASER301 trial. Long-term follow-up in LASER201 showed long PFS and OS with frontline lazertinib. Patients with and without baseline brain metastasis showed clinical benefit. Lazertinib was well tolerated, consistent…

*April 2024* IP is an effective treatment method for the EGFR-TKI-failed NSCLC-LM with a median OS of 12 months. Previous intrathecal methotrexate/cytarabine and whole-brain radiotherapy didn't have significant difference on IP treatment. IP is a safe treatment method for the EGFR-TKI-failed NSCLC-LM with tolerated adverse events. IP should be recommended…

*April 2024* Highlights Osimertinib is currently the common first-line therapy in EGFR-mutated non-small cell lung cancer patients. Understanding primary and acquired resistance mechanisms to osimertinib is crucial in choosing subsequent therapy strategy. Treatment after osimertinib must be tailored according to type of progression and detection of resistance mechanisms. Therapeutic strategies targeting…

*February 2024* The combination of osimertinib with platinum-pemetrexed led to improved central nervous system (CNS) efficacy vs osimertinib alone among patients with EGFR-mutated non–small cell lung cancer (NSCLC), according to findings from the phase 3 FLAURA2 study (NCT04035486).1 The phase 3 trial included 118 of 279 patients in the combination…

*February 2024* Co-occurring genetic alterations in solid tumors are a critical and influential prognostic factor that holds substantial importance in understanding the disease progression and guiding treatment strategies. Tumor cells acquire somatic mutations in both oncogenes and tumor suppressor genes (TSGs) leading to tumorigenesis.1  The event of multiple mutations emerging…