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*October 2021* The discovery of the EGFR driver mutation, and the subsequent development of EGFR-targeted therapy, has drastically changed the treatment and prognosis of this subgroup of patients with metastatic NSCLC. More recently, targeted therapy is also changing the treatment paradigm and outcomes for patients with early stage disease.1 Although…

*November 2021* Julie Renee Brahmer, MD, MSc, professor of oncology, co-director, Upper Aerodigestive Department, Bloomberg~Kimmel Institute for Cancer Immunotherapy, co-director, Cancer Immunology Program, director, Thoracic Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, discusses questions regarding the role of consolidative immunotherapy vs targeted therapy in locally advanced non–small cell…

*November 2021* Although next-generation TKIs, such as osimertinib (Tagrisso), have helped to overcome resistance in EGFR-mutated non–small cell lung cancer (NSCLC), a more complete understanding of resistance mechanisms may lead to the ability to overcome resistance to the next generation of these drugs, as well, according to Roy S. Herbst, MD,…

*October 2021* Highlights Acquired resistance mechanisms to osimertinib can be EGFR dependent or independent. First- and fourth-generation EGFR-TKIs are able to overcome EGFR-dependent resistance. MET and MEK inhibitors may overcome EGFR-independent resistance. Anti-HER/MET novel monoclonal antibody seems effective across multiple resistance mechanisms. Carboplatin/paclitaxel ± bevacizumab/atezolizumab represents a feasible option in…

*November 2021* Note: The article below, In Depth Overview of Tyrosine Kinase Inhibitor Treatment of EGFR+ Lung Cancer, is taken from CancerConnect and lists and explains the different generations of TKIs, their modes of action and  resistance mechanisms that develop as well as their treatments. EGFR-targeted drugs that have been shown to benefit…