Results from the phase 2 OCEAN trial show that osimertinib is effective in treating central nervous system metastases from non–small cell lung cancer in patients with certain mutations.
Osimertinib (Tagrisso) was shown to be a durable treatment for patients with central nervous system (CNS) metastasis who had non-small cell lung cancer (NSCLC) tumors that harbored EGFR T790M mutations, according to study results published in the Journal of Thoracic Oncology.1
The OCEAN study (NCT03769103) was a phase 2, 2-cohort study that looked at 66 patients with NSCLC. In the first cohort, 40 patients with tumors that harbored EGFR T790M mutations were observed versus those on first-line treatment. All 66 patients had radiation therapy (RT) naive CNS metastasis from sensitizing EGFR-mutations, 78% of patients had multiple CNS metastases. The primary endpoint of the study was brain metastasis response rate (BMRR), according to the PAREXEL criteria, which researchers found was 70% among patients (n = 20) with a solid tumor.
“In conclusion, the OCEAN study was the first to evaluate the efficacy of osimertinib against RT-naive CNS metastasis from T790M-positive NSCLC,” the researchers concluded. “The primary end point was met, and the results revealed the efficacy of osimertinib in patients with CNS metastasis harboring EGFR T790M mutations especially for EGFR-sensitizing mutation of 19-del.” Read more