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Single cell DNA-seq depicts clonal evolution of multiple driver alterations in osimertinib resistant patients

*January 2022*

Highlights

  • Clonal architecture¬†of¬†molecular alterations at the cellular level depicts cancer cell adaptation during targeted therapy.
  • Single cell sequencing from patient biopsies revealed the co-existence of two driver alterations within single cancer cells.
  • Pharmacological evaluation in patient derived models asserts the need of simultaneous inhibition of each driver.

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