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Future Medicine
Immunotherapy-based combination strategies for treatment of EGFR-TKI-resistant non-small-cell lung cancer ResearchTreatments

Immunotherapy-based combination strategies for treatment of EGFR-TKI-resistant non-small-cell lung cancer

*March 2022* Lung cancer is one of the most common malignant cancers worldwide. Specific genes are known to drive cancer growth in advanced non-small-cell lung cancer (NSCLC) and targeted therapies against these genes and their proteins have significantly improved survival. However, resistance to these therapies inevitably occurs and there is…
frontiers in oncology logo
Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report ResearchTreatments

Afatinib for the Treatment of Non-Small Cell Lung Cancer Harboring Uncommon EGFR Mutations: An Updated Database of 1023 Cases Brief Report

*April 2022* Introduction: Previously, we developed a database of 693 patients with NSCLC and uncommon EGFR mutations treated with afatinib. Here, we provide an update of >1000 patients, with more data on specific mutations. Methods: Patients were identified from a prospective database developed by Boehringer Ingelheim and via literature review. Mutations were…
Nature Magazine
Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management ResearchTreatments

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management

*May 2022* Key Points NSCLCs harboring oncogenic EGFR mutations or ALK rearrangements can be effectively treated with EGFR and ALK TKIs respectively. The third-generation TKI osimertinib and the ALK TKI lorlatinib are currently the most advanced and effective clinically approved agents in their respective NSCLC subsets; both agents are highly…