*March 2022* Adding bevacizumab to the use of erlotinib (Tarceva) in patients with EGFR-mutated non–small cell lung cancer (NSCLC) did not prolong their survival. However, both treatment arms with and without bevacizumab (Avastin) had relatively long survival durations that encouraged researchers, according to study results published in the Lancet. Read more.

*April 2022* In this video, EGFR Resisters co-founder Ivy Elkins does an interview with Rasheda Persinger, MedOnc Nurse Practioner for JADPRO’s Biomarkers in NSCLC Resource Center. It covers how to best discuss biomarker testing, treatments and symptoms with patients diagnosed with lung cancer. Your healthcare team should use clear, understandable…

*February 2022* A growing recognition of the distinct clinical, pathological, and biological features of lung cancers that arise in nonsmokers is fostering greater interest in examining the molecular underpinnings of lung cancer in this patient subset. During the past 2 decades, the treatment of patients with lung cancer has undergone…

*February 2022* The FDA’s Oncologic Drugs Advisory Committee voted against using single-country foreign data to support a biologics license application (BLA) for sintilimab injection plus pemetrexed and platinum-based chemotherapy for the frontline treatment of patients with nonsquamous non–small cell lung cancer (NSCLC). ODAC concluded that supporting data from the phase…

*February 2022*  View the video or read the transcript of expert perspectives on the management of C797S-mutated non–small cell lung cancer following failure of frontline TKIs.

*December 2021* Osimertinib is used to treat a type of lung cancer that has specific changes (mutations) in a gene called EGFR. Although tumors will usually shrink (respond) during treatment with osimertinib, they can stop responding, or become resistant, to osimertinib. A common cause of resistance is ‘MET amplification’, which…

*March 2022* This is a Phase II randomized trial of carboplatin + pemetrexed + bevacizumab with or without atezolizumab in stage 4 non-squamous NSCLC patients who harbor a sensitizing EGFR mutation or have never smoked. Learn more here.

*February 2022* Open Questions Around First-Line Treatment for EGFR Mutant Lung Cancers, Dr Helena Yu, presenter Acquired Resistance to EGFR TKIs, Dr. Katerina Politi, presenter Histological transformation and off target mechanisms are frequently identified on disease progression for patients with EGFRmutant lung cancer treated with first-line osimertinib, Dr. Noura Choudhury,…

*January 2022* Highlights: p53 and Rb alterations are confirmed as predisposing to SCLC transformation in EGFR- LUAD. Paired EGFR-LUAD/SCLC samples showed diverse clonal evolution patterns. TERT amplification is an acquired event during EGFR-LUAD to SCLC transformation. Introduction Among the different mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors (TKIs)…

*March 2022* Human Epidermal Growth Factor Receptor 2–Mutant Non–Small-Cell Lung Cancer: Continued Progress But Challenges Remain Combination of Trastuzumab, Pertuzumab, and Docetaxel in Patients With Advanced Non–Small-Cell Lung Cancer Harboring HER2 Mutations: Results From the IFCT-1703 R2D2 Trial FDA Grants Breakthrough Therapy Designation to DZD9008 for EGFR Exon20Ins-Positive NSCLC