Cancer that has spread from a solid tumor to the membranes lining the brain and spinal cord (leptomeninges) is called “leptomeningeal metastasis.” Cerebrospinal fluid (CSF) is located between the leptomeninges, in a place called the “intrathecal space.” Cancer cells within the CSF rely on iron for growth and survival. Researchers think that the study drug, deferoxamine (DFO), may be an effective treatment for leptomeningeal metastases because it helps remove iron from the body (including the CSF).
The purpose of this study is to find the highest dose of DFO that can be given safely in people with leptomeningeal metastases. Participants will receive DFO intrathecally (directly into the CSF) through a small plastic tube called an Ommaya reservoir. More information here.