Treatments

*October 2021* Sintilimab with or without a bevacizumab biosimilar injection, combined with chemotherapy yielded promising findings in a population of patients with EGFR-mutant nonsquamous non–small cell lung cancer who have previously been treated with an EGFR tyrosine kinase inhibitor. Sintilimab (Tyvyt) has yielded a promising improvement to progression-free survival (PFS)…

*July 2021* Highlights Pemetrexed-carbo plus bevacizumab and atezolizumab was effective in EGFR mutated lung cancer. Median PFS of 9.4 months, 1 year OS 72.5% in this heavily pretreated population were remarkable. Having similar efficacy, this regimen gave less toxicity compared with IMPower150 regimen. QoL was well preserved in patients which used pemetrexed…

*October 2021* Several small molecule EGFR tyrosine kinase inhibitors (TKIs) are now available for the treatment of EGFR-mutated non–small cell lung cancer (NSCLC). However, progression after TKI therapy—including with the third-generation TKI osimertinib (Tagrisso)—is inevitable. Results of several studies targeting new treatment strategies were reported at the recent International Association for…

*October 2021* For people with lung cancer, drug resistance is the major cause of relapse. A tumor might respond very well at first — maybe even shrinking down to an undetectable level — only to develop resistance and grow back. Scientists are learning that one of the ways that lung cancers…

*November 2021* Note: We have been told that there is travel reimbursement for this trial, both for the patient and the caregiver — so interested parties should not be deterred due to travel expenses and should contact the individual trial locations/contacts to learn more. From Blueprint Medicines: Currently, there are no…

*September 2021* Results from the IMpower133 and CASPIAN trials gave the small-cell lung cancer (SCLC) community something to cheer about: Both studies showed benefit with add-on PD-L1 blockade -- atezolizumab (Tecentriq) and durvalumab (Imfinzi), respectively -- and both of those agents are now part of front-line SCLC care. But initial…

*September 2021* Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC)1,2,3. Targeted therapies are approved for patients with ‘classical’ mutations and a small number of other mutations4,5,6. However, effective therapies have not been identified for additional EGFR mutations. Furthermore,…

*September 2021*      

*September 2021* Poziotinib, administered once daily at 16 mg, induced a median tumor reduction of 35% in patients with treatment-naïve non–small cell lung cancer (NSCLC) harboring HER2 exon 20 mutations, according to findings from cohort 4 of the ongoing phase 2 ZENITH20 trial (NCT03318939) that were presented at the 2021 ESMO Congress.1…