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targeted oncology
Almonertinib Induces Response in EGFR T790M-Positive NSCLC With CNS Metastases ResearchTreatments

Almonertinib Induces Response in EGFR T790M-Positive NSCLC With CNS Metastases

*May 2020* The study results indicated clinical efficacy against central nervous system metastases in a cohort of patients. Almonertinib also displayed an overall favorable safety profile. Clinical benefit was observed with almonertinib (HS-10296) as treatment of patients with EGFR T790M-mutant non–small cell lung cancer (NSCLC) who progressed on previous EGFR tyrosine kinase inhibitors…
Onc Live
Building On Immunotherapy, Preventing Acquired Resistance Are Next Steps in Lung Cancer Research ResearchTreatments

Building On Immunotherapy, Preventing Acquired Resistance Are Next Steps in Lung Cancer Research

*March 2020* Checkpoint inhibitors and next-generation TKIs have demonstrated improved survival outcomes in patients with non–small cell lung cancer (NSCLC); however, ongoing research efforts are looking to build upon the benefits with combination strategies and prevent acquired resistance to treatment, explained David P. Carbone, MD, PhD. “It's an incredibly exciting…
Cause of Resistance to 3rd-Gen EGFR-TKIs Varied in T790M-Mutated NSCLC ResearchTreatments

Cause of Resistance to 3rd-Gen EGFR-TKIs Varied in T790M-Mutated NSCLC

*March 2020* Targeted sequencing of patients with acquired resistance to third-generation EGFR tyrosine kinase inhibitors (TKIs) for EGFR T790M-mutant non-small cell lung cancer (NSCLC) revealed that resistance is associated with diverse pathways. The retrospective study looked at the genomic landscape of 113 specimens taken from patients with EGFR-mutant disease who…
Treating Patients with MET Alterations: A Q&A with Dr. Ravi Salgia ResearchTreatments

Treating Patients with MET Alterations: A Q&A with Dr. Ravi Salgia

*February 2020* Ravi Salgia, MD, PhD, is the Arthur & Rosalie Kaplan Endowed Chair in Medical Oncology and the associate director for clinical sciences at City of Hope’s Comprehensive Cancer Center. His many decades of research in MET and other oncogenic drivers has helped further lung cancer research and patient…
lungcancer.net
FDA Grants Breakthrough Therapy Designation to JNJ-6372 in Metastatic Non-Small Cell Lung Cancer ResearchTreatments

FDA Grants Breakthrough Therapy Designation to JNJ-6372 in Metastatic Non-Small Cell Lung Cancer

*March 2020* The US Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for JNJ-6372 to Janssen Pharmaceutical, a Johnson & Johnson Company. NJ-6372 is an investigational treatment for metastatic non-small cell lung cancer (mNSCLC) with epidermal growth factor receptor (EGFR) Exon 20 insertion mutations. It has been approved…