Treatments

*December 2020* John Heymach, MD, PhD Chair, Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center in a Q&A session: Targeted Oncology™: How would you reassure a patient who is eager to start treatment? HEYMACH: Patients are anxious to get their treatment started. I…

*November 2020* This new clinical trial is for those people whose EGFR lung cancer has transformed to small cell lung cancer.This trial covers travel expenses as well. Any questions can be directed to Dr. Anish Thomas at: Anish.Thomas@nci.gov. (In addition to this trial, there are other NCI trials for small…

*November 2020* Neratinib (Nerlynx) showcased early activity when used in patients with metastatic non–small cell lung cancer (NSCLC) who harbor EGFR exon 18 mutations, according to interim data from the phase 2 SUMMIT trial.1 Results demonstrated that among 10 evaluable patients who received the EGFR inhibitor, 60% (n = 6) had a…

*November 2020* In the treatment of lung tumors, alterations in MET as well as gene fusions in RET and NTRK are now established actionable drivers of oncogenesis, made evident by the availability of FDA-approved and guidelines-indicated therapies for each other these aberrations. Alexander Drilon, MD, chief of Early Drug Development…

*October 2020* Bone pain in patients with cancer is commonly caused by cancer cells that have spread to the bones, called bone metastases. Bone pain is commonly the first symptom of bone metastases and may lead to tests that will confirm the diagnosis. Treatment of bone metastases is intended to…

*November 2020* Alexander Spira, MD, PhD, a medical oncologist and director of the Virginia Cancer Specialists Research Institute and the Phase 1 Trial Program, discusses the phase 1 CHRYSALIS trial of amivantamab (JNJ-61186372) plus lazertinib (YH25448) in 2 EGFR-mutant non–small cell lung cancer patient populations, which include patients with relapsed/refractory…

*November 2020* Targeted treatments for non-small cell lung cancer: recent progress and future challenges. Some of the most common driving mutations for NSCLC occur in EGFR, the gene that encodes for the protein epidermal growth factor receptor. These EGFR mutations can be classified as common (also known as classic) mutations and rare mutations6.…

*November 2020* Liquid biopsy has emerged as a minimally invasive alternative to tumor tissue analysis for the management of lung cancer patients, especially for epidermal growth factor receptor (EGFR) oncogene addicted tumor. In these patients, despite the clear benefits of tyrosine kinase inhibitors therapy, the development of acquired resistance and…

*November 2020* MET mutations can be a resistance mechanism to TKI treatment (Tarceva, Tagrisso, etc.) Roman Perez-Soler, MD, professor in the Department of Medicine (Oncology) and Department of Molecular Pharmacology, and chief of the Department of Medicine Division of Oncology, Albert Einstein College of Medicine, discusses how MET mutations have evolved and…

*November 2020* The role of targeted therapy is rapidly expanding in the treatment paradigm of patients with non–small cell lung cancer (NSCLC), said D. Ross Camidge, MD, PhD, who added that among multiple therapeutic options for common aberrations, such as ALK, ROS1, BRAF, and MET, treatment selection should be based on more than…