Treatments

*January 2025* Data from a pooled analysis evaluating sunvozertinib (formerly DZD9008) show promising antitumor activity with a favorable safety profile for EGFR- tyrosine kinase inhibitor (TKI)-resistant non–small cell lung cancer (NSCLC). The pooled data come from 3 studies: the multinational phase 2 WU-KONG1 trial (NCT03974022), the phase 1 WU-KONG2 trial…

*January 2025* Key Takeaways Zipalertinib demonstrated a 40% ORR and 90% DCR in NSCLC patients with EGFR exon 20 insertion mutations, meeting the trial's primary endpoint. Patients previously treated with amivantamab showed a higher ORR of 50%, indicating potential efficacy in this subgroup. Common treatment-related adverse effects included rash, paronychia,…

*January 2025* Abstract Introduction Amivantamab, an EGFR-MET bispecific antibody, is approved for multiple indications in EGFR-mutated advanced NSCLC as monotherapy or combined with other agents. Intravenous amivantamab is associated with a 67% infusion-related reaction (IRR) rate. Methods The phase 2 SKIPPirr study (NCT05663866) enrolled participants with EGFR-mutated (exon 19 deletion…

*January 2025* Treatments are rapidly evolving in the second-line setting and beyond for patients with HER2-mutated non–small cell lung cancer (NSCLC), with several promising TKIs under development looking to join fam-trastuzumab deruxtecan-nxki (T-DXd; Enhertu) in this setting. Following standard of care (SOC) systemic frontline therapy, T-DXd is the NCCN guideline…

*September 2024* The Young Lung Cancer Initiative hosted a webinar with Dr. Laura Petrillo, who is a palliative care physician at MGH in Boston, MA. She is the Principal Investigator of the POISE study ("Patient-centered, Optimal Integration of Survivorship and Palliative Care") for people living with advanced lung cancer receiving…

*January 2025* The FDA has accepted and granted priority review to the biologics license application (BLA) for datopotamab deruxtecan (Dato-DXd). This investigational treatment is intended for adults with locally advanced or metastatic EGFR-mutated non–small cell lung cancer (NSCLC) who have previously received systemic therapies, including EGFR-targeted treatments. The FDA’s decision…

*May 2025* Highlights •Patients with EGFR-mutated NSCLC that progresses after osimertinib treatment need additional treatment options. •c-Met protein expression correlates with osimertinib resistance. •Teliso-V is an antibody–drug conjugate that targets c-Met protein overexpression. •Teliso-V + osimertinib had promising activity in EGFR-mut, c-Met protein-overexpressing NSCLC post-osimertinib progression. •The combination of Teliso-V…

*February 2025* In this video, Mara B. Antonoff, MD, FACS, of the University of Texas MD Anderson Cancer Center, joined Lung Cancers Today to discuss a session on operating in stage IV lung cancer held at the 61st Annual Meeting of the Society of Thoracic Surgeons (STS) in Los Angeles.…

*February 2025* In this video, Stephen Liu, MD, of the Georgetown University School of Medicine and Georgetown's Lombardi Comprehensive Cancer Center in Washington, DC, joined Lung Cancers Today to discuss the recent announcement that the phase 3 MARIPOSA trial met its final pre-specified secondary endpoint of overall survival (OS). The…