Research

*April 2025* Note: The following is an abstract from AACR 2025 presenting data on this new clinical trial, SOLARA (NCT06706076) Outcomes on tyrosine kinase inhibitor (TKI) treatment in EGFR-mutant NSCLC fall short of the durable benefit observed with next-generation targeted therapies in ALK and ROS1-driven NSCLC. We reviewed the chemical structures of 30+ existing…

*April 2025* Note: This drug is in the pipeline and is planning to open Phase 1 clinical trials in mid-2025. ALX Oncology (ALXO) has received FDA clearance for its Investigational New Drug (IND) application for ALX2004, a potential first-in-class antibody-drug conjugate (ADC) for treating EGFR-expressing solid tumors. The company plans to initiate Phase…

*April 2025* The ongoing COCOON study of a prophylactic dermatologic regimen in reducing the incidence of skin- and nail-adverse reactions in patients treated with amivantamab plus lazertinib demonstrated “early success” in meeting its phase II primary endpoint, according to a March 27 presentation during the European Lung Cancer Congress (ELCC).…

*April 2025* The investigational oral tyrosine kinase inhibitor (TKI) zongertinib showed promise in patients with previously treated HER2-mutant non-small cell lung cancer (NSCLC) in a multicohort phase Ia/Ib study. In the first cohort of 75 patients with tumors harboring a mutation in the tyrosine kinase domain, the confirmed objective response rate…

*June 2025* Targeted Oncology: What were the outcomes of the MARIPOSA trial (NCT04487080) in patients with EGFR-mutated non–small cell lung cancer (NSCLC)? Xiuning Le, MD, PhD: MARIPOSA is a global phase 3 study that enrolled a total of 1000 patients with EGFR  in the first line. The primary comparison is amivantamab plus…

*April 2025* In this episode of Lung Cancer Considered, hosts Dr. Stephen Liu and Dr. Christine Lovly discuss the significant lung cancer findings presented at the American Association for Cancer Research (AACR) 2025 Annual Meeting.  They discuss the results from the Beamion LUNG-1 trial, a phase 1a/1b dose escalation trial with…

*December 2024* Learn about the latest research on how non-small cell lung cancer can transform into small cell lung cancer and how that can impact treatment options from Jacob Berchuck, MD, Board-Certified Medical Oncologist at Emory University in this Expert Speaker video. Watch here.

*June 2025* Highlights Case series of tepotinib plus EGFR-TKIs in patients with EGFR-mutant, MET-altered NSCLC. Clinical benefit (23/25) and favorable safety shown in these heavily pretreated patients. These combinations provide a potential chemotherapy-sparing, oral therapy option. Clinical Practice Points No targeted treatments are currently approved for patients with EGFR-mutant non–small-cell lung…

*March 2025* Fort Lee, NJ, March 04, 2025 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced a  new publication from…