*September 2024*
Symptom progression was significantly delayed when patients with EGFR-mutated non–small cell lung cancer (NSCLC) were treated with amivantamab-vmjw (Rybrevant) plus lazertinib (Lazcluze) compared with osimertinib (Tagrisso) monotherapy, according to a presentation from the 2024 IASLC World Conference on Lung Cancer (WCLC).1
The study assessed the results observed in the phase 3 MARIPOSA study (NCT04487080).2 In the amivantamab plus lazertinib arm, the median time to symptomatic progression was not evaluable (NE; 95% CI, NE-NE) vs 29.3 months (95% CI, 25.3-NE) in the osimertinib arm (HR, 0.72; 95% CI, 0.57-0.91; P = .005). At 18 months, the symptomatic progression rates were 74% vs 67%, and at 24 months, they were 67% vs 59% in the combination and monotherapy arms, respectively.
“The known increase in EGFR/MET-related adverse effects [AEs] from amivantamab plus lazertinib did not meaningfully impact patient’s functioning or health-related quality of life over time,” Danny Nguyen, MD, an assistant clinical professor in the Department of Medical Oncology & Therapeutics Research at City of Hope Orange County, said during the presentation. Read more.
