*March 2025*
Fort Lee, NJ, March 04, 2025 (GLOBE NEWSWIRE) — Nuvectis Pharma, Inc. (NASDAQ: NVCT) (“Nuvectis” or the “Company”), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced a new publication from the laboratory of Prof. Ruth Keri, (Cleveland Clinic, Cleveland, OH, USA) demonstrating that the combination of NXP900 and osimertinib (the active ingredient in Tagrisso®) was superior to single agent osimertinib in vivo in a model of Epidermal Growth Factor Receptor(EGFR) mutated non-small cell lung cancer (NSCLC), and led to decreased cell proliferation and increased apoptosis in vitro. The data reported in this new publication (Cuellar-Vite et al., Molecular Cancer Research, 2025; DOI: 10.1158/1541-7786.MCR-24-030) further supports the mechanistic rationale for the combination of NXP900 and EGFR inhibitors in EGFR-mutated tumors, and further validates the data previously published by the research team at Astra Zeneca which demonstrated that the addition of NXP900 to osimertinib reverses resistance to osimertinib in osimertinib resistant cell lines.
Ron Bentsur, Chairman and Chief Executive Officer of Nuvectis, commented, “As we continue our activities toward the initiation of the Phase 1b program of NXP900, we are very pleased to see yet another independently generated dataset from a highly reputable research institution demonstrating the synergistic effect of adding NXP900 to osimertinib in EGFR mutated NSCLC. With the Phase 1a dose escalation study nearing completion, we are excited about the potential opportunities presented by NXP900 in therapeutic areas of unmet medical need, both as a single agent and in combination with market-leading anti-cancer drugs.” Read more.
