*June 2024*
Encouraging trends were seen with osimertinib and platinum-pemetrexed chemotherapy in patients with EGFR-mutated advanced non–small cell lung cancer in the phase 3 FLAURA2 study.
Findings of a second interim analysis of overall safety (OS) showed encouraging trends for osimertinib (Tagrisso) and platinum-pemetrexed chemotherapy over osimertinib monotherapy in patients with EGFR-mutated advanced non–small cell lung cancer (NSCLC), according to results from the phase 3 FLAURA2 study (NCT04035486).
The median OS of the combination arm was not reached vs 36.7 months for the osimertinib-alone arm (HR, 0.75; 95% CI, 0.57-0.97; P = .02800).1 The combination also showed favorable postprogression outcomes for time to first subsequent treatment (TFST; HR, 0.73; 95% CI, 0.56-0.94), time to second progression after FST (PFS2; HR, 0.70; 95% CI, 0.52-0.93), and time to second subsequent treatment (TSST; HR, 0.69; 95% CI, 0.65-1.24). Read more.
