Neratinib Shows Early Activity in EGFR Exon 18–Mutated, Metastatic NSCLC
Neratinib (Nerlynx) showcased early activity when used in patients with metastatic non–small cell lung cancer (NSCLC) who harbor EGFR exon 18 mutations, according to interim data from the phase 2 SUMMIT trial.1
Results demonstrated that among 10 evaluable patients who received the EGFR inhibitor, 60% (n = 6) had a partial response (PR), with 40% (n = 4) of patients experiencing a confirmed PR. Moreover, 80% (n = 8) of patients derived clinical benefit with neratinib; this was defined as a confirmed complete response, PR, or stable disease for at least 16 weeks. The median duration of response (DOR) with the agent was 7.5 months, while the median progression-free survival (PFS) was 9.1 months. Read more.